Adherence to Hunger Training Using Blood Glucose Monitoring
Adherence to Hunger Training Using Blood Glucose Monitoring
The idea that using finger prick blood glucose monitoring to train individuals to eat only when hungry appeared to be a promising method for weight management, based on the results from a group of researchers. However, neither this original study, nor an offshoot from these authors reported on adherence, a critical consideration for determining success. Thus we repeated the Ciampolini protocol (protocol A) using an adaptive design, which allowed us to determine if an alternative blood glucose cut-off might be more suitable. In fact, we found that only our adaptive version of hunger training (protocol B) was feasible, in terms of meeting all three criteria: study retention, adherence to measuring blood glucose, and adherence to eating below the blood glucose cut-off. It is difficult to compare our findings as neither of the previous studies reported on feasibility per se. However, both previous studies reported retention of 80 % of participants, which is likely comparable to our retention rates, considering their longer duration.
We anticipated that adherence to measuring blood glucose prior to every eating occasion would be an issue, however this did not seem to be the case. Participants measured their blood glucose before nearly every meal over this two-week trial. Our qualitative data suggests that participants thought that the pain and hassle of pricking their fingertips and measuring their blood glucose was not as bad as they had originally expected. Although our adherence to measuring blood glucose was considerably higher than that reported with diabetics, this is likely to be influenced by the short-term nature of our trial.
While both the original (protocol A) and adapted (protocol B) protocols achieved our criteria for success of feasibility in terms of retention and adherence to measuring blood glucose, only the protocol B met the criterion for adherence to eating below the blood glucose cut-off. Participants' difficulty of adhering to only eating when their blood glucose was under 4.7 mmol/L is consistent with large surveys that show that this concentration is below the fasting glucose level for the majority of non-diabetic adults. Thus adapting our protocol to use an individualised blood glucose cut-off substantially improved adherence to only eating when blood glucose was below the cut-off. Furthermore, this adaptation might improve weight loss success as well, at least over the short-term. Our overweight participants lost 1.5 kg on average over the fortnight, with those following protocol B losing nearly twice as much weight compared with protocol (although this difference did not reach statistical significance). This finding was intriguing given we anticipated that the more lenient cut-off (protocol B) would diminish rather than enhance weight loss. However, both the diary information and the accompanying qualitative interviews showed that protocol B was more successful at encouraging participants to only eat when hungry. One limitation of our data is that although we requested brief dietary information as part of the two-week diary, this was not detailed enough to allow energy intake to be calculated. Thus exactly how this more lenient cut-off changed dietary intake is uncertain. Furthermore our trial only lasted two weeks and longer follow-up is required to determine whether hunger training offers a viable method for sustained weight loss. As hunger training will be one support strategy in the upcoming SWIFT trial, we will have the opportunity to examine the effectiveness of hunger training on weight loss over two years. However, our findings do support those of Ciampolini et al. who demonstrated an average weight loss of 5.8 kg over 5 months in overweight participants.
Our findings of only a weak correlation between hunger and blood glucose are in agreement with the range of results reported in the literature. The weak and inconsistent association between hunger and blood glucose was the most problematic element for participants, as evident in their feedback. However, most participants felt that measuring blood glucose still provided valuable feedback and was crucial for modifying their eating behaviour, irrespective of its limitations. It seems as if the benefits of objective biofeedback provided by measuring their blood glucose levels enhances the benefits of monitoring appetite and dietary intake. Similarly, self-monitoring of blood glucose in diabetics has been shown to improve adherence to nutritional recommendations and decrease body weight. Furthermore, the necessity to measure blood glucose concentrations required participants to record their appetite and blood glucose results at that instant, rather than hours later, which may be beneficial as a shorter time interval between eating and dietary self-monitoring has been shown to be significantly associated with weight loss.
The main strength of this feasibility study is our careful measure of adherence, which has not previously been described for this intriguing weight management strategy. Feasibility and pilot studies are an important step before a large trial, and are especially useful when feasibility objectives and success criteria are defined a priori. Including an adaptive design approach helped us to efficiently find the most suitable blood glucose cut-off for our participants, which appears to be an improvement over the original method. This study provided us with confidence about the feasibility of the hunger training method in general, and knowledge that an individualised blood glucose cut-off is the most viable approach. Hunger training may provide an effective strategy for weight loss by teaching people to eat according to their physical hunger rather than in response to environmental, social, or emotional cues. Based on our findings, the SWIFT trial will include our adapted version of hunger training as one of four intervention arms. However, our study also has some limitations. As befitting a feasibility study, it was relatively short, but was based on the original protocol that showed the majority of participants were trained after two weeks. While it would have been interesting to use continuous monitoring in all participants, it was cost prohibitive. However, with the advancements in non-invasive glucose monitoring, such as using contact lenses and temporary tattoos, continuous (and pain-free) blood glucose monitoring is likely to become more affordable and accessible.
Discussion
The idea that using finger prick blood glucose monitoring to train individuals to eat only when hungry appeared to be a promising method for weight management, based on the results from a group of researchers. However, neither this original study, nor an offshoot from these authors reported on adherence, a critical consideration for determining success. Thus we repeated the Ciampolini protocol (protocol A) using an adaptive design, which allowed us to determine if an alternative blood glucose cut-off might be more suitable. In fact, we found that only our adaptive version of hunger training (protocol B) was feasible, in terms of meeting all three criteria: study retention, adherence to measuring blood glucose, and adherence to eating below the blood glucose cut-off. It is difficult to compare our findings as neither of the previous studies reported on feasibility per se. However, both previous studies reported retention of 80 % of participants, which is likely comparable to our retention rates, considering their longer duration.
We anticipated that adherence to measuring blood glucose prior to every eating occasion would be an issue, however this did not seem to be the case. Participants measured their blood glucose before nearly every meal over this two-week trial. Our qualitative data suggests that participants thought that the pain and hassle of pricking their fingertips and measuring their blood glucose was not as bad as they had originally expected. Although our adherence to measuring blood glucose was considerably higher than that reported with diabetics, this is likely to be influenced by the short-term nature of our trial.
While both the original (protocol A) and adapted (protocol B) protocols achieved our criteria for success of feasibility in terms of retention and adherence to measuring blood glucose, only the protocol B met the criterion for adherence to eating below the blood glucose cut-off. Participants' difficulty of adhering to only eating when their blood glucose was under 4.7 mmol/L is consistent with large surveys that show that this concentration is below the fasting glucose level for the majority of non-diabetic adults. Thus adapting our protocol to use an individualised blood glucose cut-off substantially improved adherence to only eating when blood glucose was below the cut-off. Furthermore, this adaptation might improve weight loss success as well, at least over the short-term. Our overweight participants lost 1.5 kg on average over the fortnight, with those following protocol B losing nearly twice as much weight compared with protocol (although this difference did not reach statistical significance). This finding was intriguing given we anticipated that the more lenient cut-off (protocol B) would diminish rather than enhance weight loss. However, both the diary information and the accompanying qualitative interviews showed that protocol B was more successful at encouraging participants to only eat when hungry. One limitation of our data is that although we requested brief dietary information as part of the two-week diary, this was not detailed enough to allow energy intake to be calculated. Thus exactly how this more lenient cut-off changed dietary intake is uncertain. Furthermore our trial only lasted two weeks and longer follow-up is required to determine whether hunger training offers a viable method for sustained weight loss. As hunger training will be one support strategy in the upcoming SWIFT trial, we will have the opportunity to examine the effectiveness of hunger training on weight loss over two years. However, our findings do support those of Ciampolini et al. who demonstrated an average weight loss of 5.8 kg over 5 months in overweight participants.
Our findings of only a weak correlation between hunger and blood glucose are in agreement with the range of results reported in the literature. The weak and inconsistent association between hunger and blood glucose was the most problematic element for participants, as evident in their feedback. However, most participants felt that measuring blood glucose still provided valuable feedback and was crucial for modifying their eating behaviour, irrespective of its limitations. It seems as if the benefits of objective biofeedback provided by measuring their blood glucose levels enhances the benefits of monitoring appetite and dietary intake. Similarly, self-monitoring of blood glucose in diabetics has been shown to improve adherence to nutritional recommendations and decrease body weight. Furthermore, the necessity to measure blood glucose concentrations required participants to record their appetite and blood glucose results at that instant, rather than hours later, which may be beneficial as a shorter time interval between eating and dietary self-monitoring has been shown to be significantly associated with weight loss.
The main strength of this feasibility study is our careful measure of adherence, which has not previously been described for this intriguing weight management strategy. Feasibility and pilot studies are an important step before a large trial, and are especially useful when feasibility objectives and success criteria are defined a priori. Including an adaptive design approach helped us to efficiently find the most suitable blood glucose cut-off for our participants, which appears to be an improvement over the original method. This study provided us with confidence about the feasibility of the hunger training method in general, and knowledge that an individualised blood glucose cut-off is the most viable approach. Hunger training may provide an effective strategy for weight loss by teaching people to eat according to their physical hunger rather than in response to environmental, social, or emotional cues. Based on our findings, the SWIFT trial will include our adapted version of hunger training as one of four intervention arms. However, our study also has some limitations. As befitting a feasibility study, it was relatively short, but was based on the original protocol that showed the majority of participants were trained after two weeks. While it would have been interesting to use continuous monitoring in all participants, it was cost prohibitive. However, with the advancements in non-invasive glucose monitoring, such as using contact lenses and temporary tattoos, continuous (and pain-free) blood glucose monitoring is likely to become more affordable and accessible.
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